Interventions for patients with prostate cancer on active surveillance: a narrative review
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View abstract on PubMed
Summary
This summary is machine-generated.Non-surgical interventions for early prostate cancer on active surveillance (AS) show promise. Androgen receptor pathway inhibitors (ARPIs) may delay progression, while lifestyle changes offer well-tolerated options, but more research is needed.
Area Of Science
- Oncology
- Urology
- Evidence-based Medicine
Background
- Active surveillance (AS) is a management strategy for early prostate cancer (PCa).
- There is a need to evaluate non-surgical interventions to manage PCa during AS.
- Contemporary evidence on these interventions requires synthesis.
Purpose Of The Study
- To review current evidence for non-surgical interventions in early prostate cancer patients undergoing AS.
- To assess the efficacy and safety of various interventions.
Main Methods
- Literature search of PubMed, Medline, and Embase databases (2011-present).
- Inclusion of randomized controlled trials (RCTs) and cohort studies.
- Focus on interventions for PCa patients on AS.
Main Results
- Androgen receptor pathway inhibitors (ARPIs) show potential in delaying progression to aggressive PCa but have toxicity concerns.
- Nutraceuticals, diet, and exercise are well-tolerated but lack large-scale RCT evidence for oncological benefit.
- Biomarkers and standardized AS criteria are needed for better risk stratification and monitoring.
Conclusions
- Current evidence for interventions in AS is mainly from small studies.
- Short-term ARPIs are considered for higher-risk patients; lifestyle interventions for lower-risk patients.
- Large RCTs incorporating biomarkers are essential to validate interventions and long-term outcomes.
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