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A falsely low lactate: discrepancies in lactate measurement between blood gas and core laboratory instruments due to
Nadia M Alqurini1, Bhawana Adhikari2, Hoda A Hagrass2
1Department of Nephrology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Introduction:
Laboratory tests play a crucial role in diagnosing and managing illness. Accurate interpretation, which includes evaluating false-negative and false-positive results, is essential for guiding appropriate clinical interventions and ensuring patient safety.
Methods:
We present a case involving clinically significant discrepancies in lactate measurements in a patient with acute myeloid leukemia and diabetic ketoacidosis.
Results:
These discrepancies were caused by interference from elevated levels of ketone bodies-specifically, β-hydroxybutyrate-which may have delayed recognition of the severity of the patient's condition.
Discussion:
Dilution and spike experiments suggested potential interferences in core laboratory instruments using the Trinder reaction, leading to inaccurate lactate readings.
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