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Chemical constituents from the whole herbs of Vincetoxicum mongolicum Maxim
Xiaoli Ma1, Jingjing Tian1, Ruru Sun1
1Key Laboratory for Chemical Engineering and Technology of State Ethnic Affairs Commission, School of Chemistry and Chemical Engineering, North Minzu University, Yinchuan, P.R. China.
Abstract:
A new polyphenolic compound, vinmonone (1), together with 15 previously reported compounds (2 - 16) were isolated and characterised from the whole herbs of Vincetoxicum mongolicum Maxim. The structure of new compound (1) was determined through NMR and HR-ESI-MS spectroscopic data analysis. Biological assay results showed that compounds 7 - 9, 11 and 12 showed antioxidant activity with IC50 5.6, 11.8, 5.4, 6.2, 11.2 ug/mL, respectively, compounds 7, 9 and 11 showed tyrosinase inhibitory activity with IC50 33.1, 30.1, 34.7 ug/mL, respectively. In addition, compounds 3 and 16 showed anti-bacterial activity against Staphylococcus aureus with MIC 25.1, 20.5 ug/mL, respectively, compounds 3 and 7 also showed anti-fungi activity against Candida albicans with MIC 3.4, 4.8 μg/mL, respectively. These finding provides a scientific basis for elucidating the chemical diversity and activity of V. mongolicum.
