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Updated: Jan 15, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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FBXO44 Regulates FOXP1 Degradation Through AURKA-Dependent Phosphorylation to Promote Colorectal Cancer Progression

Hongxu Nie1,2,3, Hengjie Xu1,2,3,4, Sheng Yang1,2,3

  • 1Department of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|October 6, 2025
PubMed
Abstract

Keywords:
FBXO44FOXP1colorectal cancerphosphorylationubiquitination

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