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Microbial Biosensors

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Related Experiment Video

Updated: Jun 22, 2026

Microfluidic-based Electrotaxis for On-demand Quantitative Analysis of Caenorhabditis elegans' Locomotion

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Electric Field-Driven Bacterial Membrane Disintegration with Real-Time Electrical Response in SWCNT Bioelectronic

Sovanlal Mondal¹, Asima Pradhan², Suman Mandal³

¹School of Nano Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India.

ACS Applied Bio Materials

|October 6, 2025

Summary

This study developed a bioelectronic platform using single-walled carbon nanotubes (SWCNTs) and bacteria to observe real-time charge transport. Findings reveal SWCNTs

Keywords:

SWCNT bioelectronics bacterial–electrode interaction electric field-induced membrane disruption extracellular electron transfer real-time electrical sensing

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Published on: January 31, 2020

Area of Science:

Bioelectronics
Nanomaterials Science
Microbial Electrochemistry

Background:

Investigating microbial-electrode interfaces is crucial for biosensing and bioelectronics.
Understanding charge transport dynamics at these interfaces remains a challenge.

Purpose of the Study:

To develop and characterize a bioelectronic platform for real-time analysis of charge transport at microbial-electrode interfaces.
To elucidate the mechanisms governing electron exchange and interfacial behavior.

Main Methods:

Fabrication of a bioelectronic device integrating acid-functionalized single-walled carbon nanotubes (SWCNTs) with Escherichia coli and gold electrodes.
Utilizing Kelvin probe force microscopy (KPFM) to map contact potential differences and charge redistribution.
Monitoring current responses under applied bias with varying bacterial concentrations.

Main Results:

Acid-functionalized SWCNTs improved dispersibility and electron transfer in aqueous environments.
The platform detected transient current spikes and stabilization phases upon bacterial introduction, indicating dynamic attachment and electron exchange.
KPFM confirmed localized charge redistribution and identified depletion regions influencing device conductivity.
Bacterial concentration directly correlated with device response, providing mechanistic insights.

Conclusions:

The developed SWCNT-based platform enables real-time investigation of nanobioelectronic interactions.
This work provides foundational understanding for microbial charge transfer mechanisms.
Highlights potential applications in microbial sensing, environmental monitoring, and advanced bioelectronics.