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Updated: Jan 6, 2026
Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Association between VDR Apa I polymorphism and subclinical hypothyroidism in patients with polycystic ovary syndrome:
Li Liu1, Huixian Kang1, Xuli Li1
1Reproductive Center, Yinchuan Maternal and Child Health Hospital Affiliated to Ningxia Medical University, Ningxia, China.
Purpose:
To investigate the association between vitamin D receptor (VDR) gene polymorphisms and sub-clinical hypothyroidism (SCH) risk in polycystic ovary syndrome (PCOS) patients.
Methods:
Forty-four PCOS patients and 24 controls were enrolled. VDR gene sequences, lipid profiles, and thyroid function were analyzed, with stratification by SCH status for group comparisons.
Results:
PCOS patients showed significant differences in fasting glucose, triglycerides, and BMI vs. controls. SCH patients exhibited distinct Apa I genotypes (P < 0.05), with the AC genotype rate (76.47%) significantly higher in PCOS + SCH vs. other groups. Unadjusted/adjusted ORs for SCH patients with the AC genotype were 4.2 (95% CI 1.40-13.10), 5.01 (95% CI 1.53-16.38), and 6.25 (95% CI 1.69-23.09). No other polymorphisms were significant.
Conclusion:
This study revealed that the VDR Apa I genotype (AC as a distinct risk factor) was associated with SCH in PCOS patients, suggesting new genetic insights.
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