From Chemistry to Clinic: Polysaccharide-Bioceramic Composites for Tissue Engineering Applications.

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Regenerative Medicine

Background:

• Composite scaffolds combining polysaccharides and bioceramics are crucial for next-generation tissue engineering.
• Polysaccharides mimic extracellular matrix components, promoting cell adhesion and proliferation.
• Bioceramics enhance mechanical properties and provide osteoconductive benefits.

Purpose of the Study:

• To critically review alternative polysaccharides, bioceramics, and composite materials for tissue engineering and biomedical applications.
• To highlight advanced fabrication strategies, including 3D printing and electrospinning.
• To explore the translational potential of polysaccharide-bioceramic composites in personalized medicine.

Main Methods:

• Literature review of polysaccharide-bioceramic composites in tissue engineering.
• Analysis of advanced fabrication techniques like 3D printing and electrospinning.
• Evaluation of the biological performance and mechanical properties of composite scaffolds.

Main Results:

• Polysaccharide-bioceramic composites demonstrate enhanced mechanical and biological properties.
• Applications extend beyond bone and dental TE to wound healing, cartilage, cardiac, and muscle regeneration.
• These composites support drug delivery, angiogenesis, and neurogenesis.

Conclusions:

• Polysaccharide-bioceramic composites offer a versatile platform for advanced regenerative therapies.
• Mimicking the native extracellular matrix, these materials promote cell growth and tissue regeneration.
• Integrating emerging technologies provides sustainable materials for next-generation scaffolds meeting clinical needs.