Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Left Atrial Strain as a Predictor of Postoperative Atrial Fibrillation After Mitral Valve Replacement for Mitral Stenosis: A Prospective Observational Study.

Journal of cardiothoracic and vascular anesthesia·2026
Same author

Autism spectrum disorder identification using machine learning models on MRI data.

Scientific reports·2026
Same author

Exploring the Involvement of RSPO1 Gene Variations in 46,XX DSD Patients With Mullerian Agenesis and/or Gonadal Dysgenesis-An Indian Study.

The journal of obstetrics and gynaecology research·2026
Same author

OGTCN-E-MGO: an optimized deep learning framework for EEG-based schizophrenia detection.

Physical and engineering sciences in medicine·2026
Same author

Haplotype-based association of CYB5A gene polymorphisms (rs1790834 and rs1790858) with polycystic ovary syndrome in a south Indian cohort.

Gene·2025
Same author

A novel UNet-SegNet and vision transformer architectures for efficient segmentation and classification in medical imaging.

Physical and engineering sciences in medicine·2025
Same journal

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial).

Journal of visualized experiments : JoVE·2026
Same journal

A Standardized Ex Vivo Porcine Oromucosal Model for Evaluating Peptide Fluxes.

Journal of visualized experiments : JoVE·2026
Same journal

Lightweight English Text Classification with Deep Learning Based on Complex System Theory.

Journal of visualized experiments : JoVE·2026
Same journal

Integrating Artificial Intelligence-Assisted Translation Support into English Courses: Effects on Translation Accuracy, Perceived Stress, and Anxiety.

Journal of visualized experiments : JoVE·2026
Same journal

A Toxin-Based Counter-Selection System for Markerless Gene Deletion and High-Density Tn5 Transposon Mutagenesis in Pectobacterium brasiliense.

Journal of visualized experiments : JoVE·2026
Same journal

Seamless Multimodal Human-Robot Communication: Integration Techniques in Human-Computer Interaction.

Journal of visualized experiments : JoVE·2026
See all related articles

Related Experiment Video

Updated: Jan 15, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.0K

A Multifunctional, Embedded-based, Bluetooth-enabled, Programmable, Biphasic-waveform Stimulator with Real-time

Paul V Milner1, Philips Zachariah2, Jijo Francis3

  • 1Department of Electrical Engineering, National Institute of Technology Manipur (NITM); Department of Electrical and Electronics Engineering, Christ College of Engineering; vithayathilmilner@gmail.com.

Journal of Visualized Experiments : Jove
|October 6, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed a new Bluetooth deep brain stimulation (DBS) device for small animals. This wireless system enables flexible waveform control and neural signal recording for advanced neuromodulation research.

More Related Videos

Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation
08:50

Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation

Published on: August 20, 2019

15.0K
Electroencephalographic Signal Acquisition Framework for Neurodiverse: A Case Study of Dolphin-Assisted Therapy
07:21

Electroencephalographic Signal Acquisition Framework for Neurodiverse: A Case Study of Dolphin-Assisted Therapy

Published on: June 27, 2025

433

Related Experiment Videos

Last Updated: Jan 15, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.0K
Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation
08:50

Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation

Published on: August 20, 2019

15.0K
Electroencephalographic Signal Acquisition Framework for Neurodiverse: A Case Study of Dolphin-Assisted Therapy
07:21

Electroencephalographic Signal Acquisition Framework for Neurodiverse: A Case Study of Dolphin-Assisted Therapy

Published on: June 27, 2025

433

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Devices

Background:

  • Current deep brain stimulation (DBS) research tools for small animals lack waveform flexibility and wireless control.
  • Preclinical research requires advanced tools for precise neuromodulation and neural signal acquisition.

Purpose of the Study:

  • To develop a lightweight, Bluetooth-enabled DBS device for preclinical research in freely moving small animals.
  • To enable programmable, charge-balanced biphasic waveforms and simultaneous neural signal recording.

Main Methods:

  • Integrated off-the-shelf components for current regulation, signal amplification, and analog-to-digital conversion.
  • Managed system functions using a low-power microcontroller and programmed waveforms via nRF Connect.
  • Assembled the device on a 30 x 30 mm PCB and validated performance through in vitro saline and load resistance testing.

Main Results:

  • Demonstrated reliable current output across varying load impedances.
  • Confirmed effective saline operation without waveform degradation.
  • Achieved high-fidelity neural signal recording with a signal-to-noise ratio exceeding 35 dB.

Conclusions:

  • The developed DBS device is suitable for closed-loop neuromodulation experiments in preclinical research.
  • The system's wireless control and waveform flexibility address current limitations in animal models.
  • This technology provides a foundation for future translational studies in deep brain stimulation therapy.