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Self-Reported Race as a Determinant of Differential Methylation in Peripheral Artery Disease

Lindsey K Stolze1,2, Alexander E Sullivan3, Yu Wang1,2

  • 1Department of Biostatistics (L.K.S., Y.W., Q.S.), Vanderbilt University Medical Center, Nashville, TN.

Circulation
|October 6, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
DNA methylationepigenomicsperipheral arterial diseaseracial groups

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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