Outcomes in Patients With Immune Checkpoint Inhibitor-Related Myopathy and Prolonged Follow-Up
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View abstract on PubMed
Summary
This summary is machine-generated.Most patients with immune checkpoint inhibitor-related myopathy achieve good functional outcomes, though residual symptoms are common. Improvement continues over 12 months, but male sex and specific symptoms indicate a worse prognosis.
Area Of Science
- Neurology
- Immunology
- Oncology
Background
- Immune checkpoint inhibitors (ICIs) are crucial cancer therapies.
- Immune-related adverse events (irAEs) are common, with myopathy being a frequent neurologic irAE.
- Long-term outcomes of ICI-related myopathy are not well-established.
Purpose Of The Study
- To evaluate the long-term outcomes of patients diagnosed with immune checkpoint inhibitor-related myopathy.
- To identify factors associated with disease course and prognosis in ICI-related myopathy.
Main Methods
- Retrospective review of patients with ICI-related myopathy at Mayo Clinic (2013-2024).
- Comparison between patients with at least 6 months of follow-up and those who died within 2 months of onset.
- Analysis of clinical presentation, treatment, and outcomes.
Main Results
- Eighty-seven percent of patients achieved a favorable outcome (irAE grade ≤2) at last follow-up, with residual symptoms in 48%.
- Most patients showed gradual improvement, even after treatment cessation.
- Male sex, bulbar, and axial involvement were associated with a poorer prognosis.
Conclusions
- Long-term functional outcomes for ICI-related myopathy are generally favorable, but residual symptoms persist in about half of patients.
- Symptom improvement can continue for over 12 months.
- Identifying specific clinical features can predict a more severe disease course, suggesting atypical pathology in refractory cases.
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