Fabrication of P25@MIL-101(Fe)@Ag Composite Material with Enhanced Antibacterial Activity

The issue of bacterial resistance poses a serious threat to human health, and the synthesis and application of silver-based nanomaterials with broad-spectrum antimicrobial activity have attracted widespread attention. To address the instability and limited antibacterial efficacy of silver nanoparticles (AgNPs), this study developed a composite material with enhanced antibacterial performance─P25@MIL-101(Fe)@Ag─by using commercial P25 titanium dioxide coated with MIL-101(Fe) as a support and loading AgNPs via an in situ tannic acid reduction method. Peroxidase-like activity assays revealed that the composite exhibited superior enzyme-mimicking activity compared to AgNPs alone. In vitro antibacterial experiments demonstrated that the composite showed significantly enhanced broad-spectrum antibacterial activity compared to AgNPs, and its bactericidal efficacy was further improved when used in combination with hydrogen peroxide. In vivo wound healing experiments on mice infected with methicillin-resistant Staphylococcus aureus (MRSA) showed that the composite effectively eliminated MRSA from the wound site and promoted wound healing, highlighting its promising potential for practical applications in treating drug-resistant bacterial infections.