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Updated: Jan 15, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

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The roles and function of circular RNA in prostate cancer

Xuan Shu1, Jiaming Wang1, Danni Chen2

  • 1Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Cancer Center, Zhejiang University, Hangzhou 310058 China.

Gene
|October 6, 2025
PubMed

Insights

Circular RNAs (circRNAs) are key regulators in biological processes and influence cancer progression. This review highlights circRNA roles in prostate cancer, offering insights into potential biomarkers and therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are non-coding RNAs with stable structures.
  • circRNAs regulate gene expression, protein interactions, and peptide encoding.
  • Prostate cancer's molecular mechanisms are not fully understood.

Purpose of the Study:

  • To review the regulatory roles and molecular mechanisms of circRNAs in prostate cancer.
  • To focus on circRNA functions in cell cycle, proliferation, apoptosis, ferroptosis, migration, invasion, metastasis, drug resistance, and the immune microenvironment.
  • To provide insights into circRNA's role, functions, and clinical applications in prostate cancer.

Main Methods:

  • Literature review of circRNAs in prostate cancer.
  • Summarization of molecular mechanisms and biological functions.
  • Analysis of potential as biomarkers and therapeutic targets.

Main Results:

  • circRNAs play significant roles in tumorigenesis and progression.
  • Specific circRNA functions identified in cell cycle, proliferation, apoptosis, ferroptosis, migration, invasion, metastasis, drug resistance, and immune microenvironment.
  • circRNAs show potential as novel biomarkers and therapeutic targets for prostate cancer.

Conclusions:

  • circRNAs are crucial regulators in prostate cancer development and progression.
  • Understanding circRNA mechanisms offers new avenues for prostate cancer diagnosis and treatment.
  • circRNAs represent promising targets for future clinical applications in prostate cancer management.
Keywords:
CircRNAMechanismsProstate cancer

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