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Impact of cardiometabolic index change on stroke risk in Chinese middle-aged and elderly: a prospective study

Mei Tian1, Xiaoyan Ma1, Jianxi Liu1

  • 1School of Public Health, Ningxia Medical University, Shengli Street, Xingqing District, Yinchuan, 750004, China.

BMC Public Health
|October 7, 2025
PubMed

Insights

Increasing cardiometabolic index (CMI) is linked to a higher risk of stroke in older Chinese adults. This study highlights the importance of monitoring CMI changes for stroke prevention strategies.

Area of Science:

  • Cardiovascular Health
  • Gerontology
  • Public Health

Background:

  • Limited data exists on the association between cardiometabolic index (CMI) changes and stroke incidence.
  • Understanding this relationship is crucial for developing targeted preventive measures.

Purpose of the Study:

  • To investigate the correlation between changes in cardiometabolic index (CMI) and the occurrence of stroke.
  • Focus on middle-aged and elderly individuals in China.

Main Methods:

  • Utilized data from the China Health and Retirement Longitudinal Study (CHARLS) with individuals aged 45 and above.
  • Calculated CMI changes over a defined period and categorized participants into 'loss', 'stable', and 'gain' groups based on CMI trends.
  • Followed participants from 2015 to 2020 to record stroke events.

Main Results:

  • A total of 4,365 participants were analyzed, with 356 (8.2%) experiencing stroke.
  • Both the 'stable' (OR=1.503) and 'gain' (OR=1.528) CMI change groups showed significantly higher odds of stroke compared to the 'loss' group.
  • A significant nonlinear relationship was identified between CMI changes and stroke risk (P<0.05).

Conclusions:

  • Demonstrated a nonlinear, positive association between cardiometabolic index changes and stroke risk in Chinese older adults.
  • Findings suggest that monitoring CMI fluctuations can aid in identifying high-risk individuals for stroke prevention.
  • Results provide a basis for developing targeted interventions to mitigate stroke incidence.
Abstract

Keywords:
CHARLESCardiometabolic indexChangesProspective studyStroke

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