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Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Formulating Smart All-in-One Chitosan Hydrogel for High Performance Wound Dressing.

Chia-Chi Lin1,2, Andi Magattang Gafur Muchlis1, Ren-Jei Chung3

  • 1Institute of Organic and Polymeric Materials, National Taipei University of Technology, No. 1, Section 3, Zhongxiao E. Rd, Daan District, Taipei, 10608, Taiwan.

Advanced Healthcare Materials
|October 7, 2025
PubMed
Summary

This study developed a novel chitosan hydrogel, enhanced with poly(N-isopropyl acrylamide) and silver nanoparticles, for improved wound healing. The smart hydrogel exhibits excellent antibacterial and thermal-responsive properties for advanced wound dressing applications.

Keywords:
antibacterialchitosan hydrogelhydrogen bondthermosensitivewound dressing

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Wound Healing Research

Background:

  • Chitosan hydrogels possess limitations in mechanical strength and film formation, hindering their use as wound dressings.
  • Developing advanced wound dressings requires materials with enhanced properties like thermosensitivity and antibacterial activity.

Purpose of the Study:

  • To design and synthesize a novel chitosan-graft-poly(N-isopropyl acrylamide) (PNIPAAm) hydrogel crosslinked with polyvinyl alcohol/polyvinyl pyrollidone (PVA/PVP).
  • To incorporate silver nanoparticles (AgNPs) into the hydrogel for enhanced antibacterial efficacy.
  • To evaluate the thermal, mechanical, swelling, antibacterial, and wound healing properties of the developed hydrogel.

Main Methods:

  • Synthesis of chitosan-graft-PNIPAAm hydrogel via crosslinking with PVA/PVP blend.
  • Incorporation of AgNPs using a co-reduction method.
  • Characterization of hydrogel properties including thermal responsiveness (particle size, transmittance), mechanical strength, swelling ratio, degradation rate, antibacterial activity against Escherichia coli, and in vivo wound healing in rats.

Main Results:

  • The hydrogel demonstrated thermosensitive behavior above 32°C, confirmed by decreased particle size and transmittance.
  • Characterization revealed a porous 3D network structure with significant intermolecular and intramolecular hydrogen bonding.
  • The hydrogel exhibited a high swelling ratio (358.86 ± 23.56%) and a degradation ratio of 86.02 ± 2.82% over 21 days.
  • Excellent antibacterial properties against Escherichia coli and accelerated wound healing in rat models were observed.

Conclusions:

  • A novel chitosan-based thermosensitive hydrogel incorporating AgNPs was successfully developed.
  • The hydrogel possesses superior physical, mechanical, and antibacterial properties, along with effective wound healing capabilities.
  • This advanced chitosan hydrogel shows significant potential as a smart, all-in-one wound dressing for accelerating tissue repair.