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Published on: August 23, 2022
Association of maternal biliary disease with hepatopancreatobiliary morbidity in offspring
Nathalie Auger1,2,3,4, Angela Magri5, Sarit Kang-Auger5
1University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.
Insights
Maternal biliary disease increases the risk of hepatopancreatobiliary conditions in children. This study highlights a significant association between maternal gallbladder issues and offspring liver and bile duct problems.
Area of Science:
- Hepatology
- Pediatric Gastroenterology
- Reproductive Health
Background:
- Maternal biliary disease is prevalent.
- The impact on offspring hepatopancreatobiliary health is largely unstudied.
Purpose of the Study:
- To investigate the association between maternal biliary disease and pediatric hepatopancreatobiliary morbidity.
- To assess risks for congenital anomalies, metabolic disorders, and disease in offspring.
Main Methods:
- Retrospective cohort study of 1,271,864 children (2006-2022) in Quebec, Canada.
- Exposure: maternal biliary disease.
- Outcomes: congenital anomalies, inborn errors of metabolism, and hepatopancreatobiliary morbidity up to age 17.
Main Results:
- Maternal biliary disease linked to higher risks of bile duct defects (RR 1.67), liver defects (RR 1.47), and inborn errors of metabolism (RR 1.41).
- Increased hospitalization rates for cholelithiasis, cholecystitis, cholangitis (HR 2.58), acute pancreatitis (HR 1.83), and metabolic dysfunction-associated steatotic liver disease (HR 2.71).
Conclusions:
- Maternal biliary disease is a significant risk factor for hepatopancreatobiliary complications in offspring.
- Findings underscore the importance of considering maternal health in pediatric liver and bile duct disease etiology.
Objectives:
Maternal biliary disease is common, but the link with offspring hepatopancreatobiliary disease has not been studied. We assessed the association between maternal biliary disease and pediatric hepatopancreatobiliary morbidity.
Methods:
We conducted a retrospective cohort study of 1,271,864 children born between 2006 and 2022 in Quebec, Canada. The exposure was maternal biliary disease. Offspring outcomes included congenital hepatopancreatobiliary anomalies, inborn errors of metabolism, and hepatopancreatobiliary morbidity between birth and age 17 years. We estimated adjusted risk ratios (RR) and hazard ratios (HR) with 95% confidence intervals (CI) for the association of maternal biliary disease with child outcomes.
Results:
A total of 95,047 children (7.5%) had mothers with biliary disease. Compared with no exposure, maternal biliary disease was associated with an increased risk of bile duct defects (RR 1.67, 95% CI 1.10-2.52), liver defects (RR 1.47, 95% CI 1.05-2.06), and inborn errors of metabolism (RR 1.41, 95% CI 1.24-1.62) in offspring. Exposed children were more likely to be hospitalized for cholelithiasis, cholecystitis, or cholangitis (HR 2.58, 95% CI 2.14-3.12), acute pancreatitis (HR 1.83, 95% CI 1.38-2.43), and metabolic dysfunction-associated steatotic liver disease (HR 2.71, 95% CI 2.07-3.54).
Conclusions:
Maternal biliary disease is associated with hepatopancreatobiliary complications in offspring.
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