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Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
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Equine Asthma Is Characterised by Severity-Dependent Correlations Between Blood Neutrophil Cholesterol Content and
Lia K Meiseberg1,2,3, AhmedElmontaser Mergani2,3, Julien Delarocque1
1Clinic for Horses, University of Veterinary Medicine, Hannover, Germany.
European Journal of Immunology
|October 7, 2025
Summary
Equine asthma (EA) severity correlates with neutrophil extracellular traps (NETs) and lower cholesterol in horse neutrophils. These findings reveal new insights into EA pathogenesis and potential inflammatory pathways.
Area of Science:
- Veterinary Medicine
- Immunology
- Respiratory Medicine
Background:
- Equine asthma (EA) is a common chronic lung condition in horses.
- Neutrophils and their extracellular traps (NETs) play a role in severe human respiratory diseases.
- Understanding NETs in EA could offer new therapeutic targets.
Purpose of the Study:
- To investigate NET-related factors in differentiating equine asthma severity.
- To explore NET-related mechanisms in equine asthma pathogenesis.
- To analyze neutrophil cholesterol content in relation to EA severity and NET formation.
Main Methods:
- Quantification of NETs and related factors in blood and bronchoalveolar lavage fluid (BALF).
- Analysis of circulating anti-neutrophil cytoplasmic antibodies (ANCAs).
- Assessment of neutrophil cholesterol content and correlation with NET formation and hypoxia.
Main Results:
- Increased cell activation and dysregulated NET regulators in BALF with higher EA severity.
- Elevated ANCAs (NET-autoantibodies) in severely affected horses.
- NET formation by circulating neutrophils increased with EA severity, linked to decreased neutrophil cholesterol and hypoxia.
Conclusions:
- NET-related factors and neutrophil cholesterol levels can differentiate equine asthma severity.
- Decreased neutrophil cholesterol is associated with increased NET formation and hypoxia in EA.
- These findings suggest a systemic cholesterol-associated inflammatory component in equine asthma progression.
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