Construction of osteoporosis diagnosis model based on bioinformatics analysis of autophagy-related genes
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View abstract on PubMed
Summary
This summary is machine-generated.Autophagy-related genes (ATGs) are crucial for bone health in osteoporosis (OP). This study identifies key ATGs, including ras-related C3 botulinum toxin substrate 1, epidermal growth factor receptor, and cathepsin D, offering new diagnostic and therapeutic strategies for OP.
Area Of Science
- Biomedical Science
- Molecular Biology
- Genetics
Background
- Osteoporosis (OP) is a significant global health concern.
- Bone cell homeostasis is regulated by autophagy, but specific autophagy-related genes (ATGs) influencing OP remain largely unknown.
- Understanding ATGs is vital for elucidating OP pathogenesis and developing targeted treatments.
Purpose Of The Study
- To screen differentially expressed autophagy-related genes (DE-ATGs) in osteoporosis.
- To explore the role of autophagy-related biomarkers in OP development.
- To identify potential diagnostic and therapeutic targets for OP.
Main Methods
- Downloaded and analyzed the GSE56815 dataset from the Gene Expression Omnibus database.
- Screened differentially expressed genes in OP and intersected them with human autophagy genes to identify DE-ATGs.
- Utilized bioinformatics tools including R software, gene ontology, Kyoto Encyclopedia of Genes and Genomes, Metascape, DisGeNet, and gene set enrichment analysis.
- Employed Least Absolute Shrinkage and Selection Operator, cross-validation, and receiver operating characteristic curve analysis to identify key diagnostic genes.
Main Results
- Identified key DE-ATGs implicated in osteoporosis.
- Ras-related C3 botulinum toxin substrate 1, epidermal growth factor receptor, and cathepsin D were identified as core DE-ATGs with high diagnostic value for OP.
- These genes show potential as novel biomarkers for OP diagnosis.
Conclusions
- Autophagy plays a critical role in the pathogenesis of osteoporosis.
- Specific DE-ATGs, including ras-related C3 botulinum toxin substrate 1, epidermal growth factor receptor, and cathepsin D, are promising biomarkers for OP diagnosis.
- These findings offer new avenues for the diagnosis and treatment of osteoporosis.
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