Novel key genes in the pathogenesis of recurrent pelvic organ prolapse identified via bioinformatics analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Recurrent pelvic organ prolapse (POP) may be linked to specific genes. Researchers identified cell death-inducing DFFA-like effector (CIDEA) and hemoglobin subunit delta (HBD) as potential key genes in POP recurrence.
Area Of Science
- Genomics
- Urogynecology
- Molecular Biology
Background
- Pelvic organ prolapse (POP) recurrence is a significant clinical challenge.
- Understanding the genetic underpinnings of POP recurrence is crucial for developing targeted therapies.
- Limited research has focused on identifying key genes associated with POP recurrence.
Purpose Of The Study
- To screen and identify hub genes associated with the recurrence of pelvic organ prolapse (POP).
- To explore the potential diagnostic and therapeutic value of identified genes in POP recurrence.
Main Methods
- Utilized the Gene Expression Omnibus (GEO) dataset GSE28660, comparing gene expression in uterosacral ligaments from recurrent POP and primary POP patients.
- Performed differential gene expression analysis, functional enrichment analysis, and protein-protein interaction (PPI) network analysis.
- Employed the CIBERSORT algorithm to analyze immune cell infiltration differences between recurrent and primary POP tissues.
Main Results
- Identified 116 genes associated with recurrent POP, including 84 upregulated and 32 downregulated genes.
- Discovered two hub genes, cell death-inducing DFFA-like effector (CIDEA) and hemoglobin subunit delta (HBD), potentially involved in POP recurrence pathogenesis.
- Observed distinct immune cell infiltration patterns between recurrent and primary POP tissues.
Conclusions
- Cell death-inducing DFFA-like effector (CIDEA) and hemoglobin subunit delta (HBD) are identified as key genes potentially contributing to pelvic organ prolapse (POP) recurrence.
- These identified hub genes may offer potential biomarkers for diagnosing and treating recurrent POP.
- Further investigation into the role of these genes and immune cell infiltration in POP recurrence is warranted.
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