Chest Computed Tomography-Based Radiomics and Machine Learning for Classifying Mediastinal Lymphadenopathy Caused By...

To evaluate the role of chest CT radiomics in classifying mediastinal lymphadenopathy caused by hematologic malignancies and abdominopelvic solid cancers.

A total of 231 patients with mediastinal lymphadenopathy were selected from the Mediastinal-Lymph-Node-SEG collection in The Cancer Imaging Archive, including 145 patients with hematologic malignancies (74 with chronic lymphocytic leukemia and 71 with lymphoma) and 86 with abdominopelvic solid cancers. Patients were randomly stratified into train and test sets in a 7:3 ratio. Radiomics features were extracted from enhanced CT images of mediastinal lymph nodes, followed by feature selection using univariate analysis and least absolute shrinkage and selection operator regression. A support vector machine algorithm was used to develop classification models, with performance evaluated using the area under the receiver operating characteristic curve (AUC-ROC), accuracy, and 95% CI.

For differentiating mediastinal lymphadenopathy between hematologic malignancies and abdominopelvic solid cancers, the model incorporated 23 features and achieved an AUC-ROC of 0.931 (95% CI: 0.891-0.971) and an accuracy of 0.866 in the train set, and an AUC-ROC of 0.830 (95% CI: 0.730-0.929) and an accuracy of 0.759 in the test set. For distinguishing chronic lymphocytic leukemia from lymphoma, the model utilized 4 features, achieving an AUC-ROC of 0.880 (95% CI: 0.813-0.947) and an accuracy of 0.752 in the train set, and an AUC-ROC of 0.872 (95% CI: 0.763-0.982) and an accuracy of 0.836 in the test set.

Chest CT radiomics shows promise for classifying mediastinal lymphadenopathy in patients with hematologic malignancies and abdominopelvic solid cancers.