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Updated: Jan 15, 2026
Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
Cyanoacrylate glue for securing peripherally inserted intravenous catheters in the emergency department: A
João Vitor Sciorilli1, João Pedro Bogossian Remaili1, Davi Barbosa Pereira da Silva2
1Faculdade de Medicina do ABC, Santo André-SP, Brazil.
Background:
Intravenous catheters (IVCs) are a common medical device, used in 70% of hospital patients. Due to their high failure ratio (35%-50%) and complications, we aimed to perform a systematic review and meta-analysis to assess the efficacy of Cyanoacrylate Glue (CG) use in preventing IV complications at the Emergency Department.
Methods:
This study was registered in PROSPERO on February 5, 2025, with registry number CRD42025642588 and received no financial support. A systematic search at PubMed, Embase, and Cochrane databases was performed and only Randomized Controlled Trials about CG use for securing IVCs were included.
Results:
Primary outcomes showed no statistical significance between the groups across all four outcomes at maximum follow-up. However, in a subgroup analysis including only adult patients, CG group presented lower IVCs dislodgement and failure events. Further studies in pediatric patients are needed.
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