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Updated: Jan 15, 2026

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

The noncoding circular RNA circHomer1 regulates synaptic development and experience-dependent plasticity in the mouse

Kyle R Jenks¹, Ying Cai², Marvin Eduarte Nayan³

¹Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

|October 7, 2025

Summary

Circular RNAs (circRNAs) play a key role in brain plasticity. This study shows circHomer1 is essential for visual cortex synaptic development and learning from experience.

Keywords:

Developmental biology Genetics Molecular biology Neuroscience

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Last Updated: Jan 15, 2026

Identification of Circular RNAs using RNA Sequencing

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Published on: November 14, 2019

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex

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Published on: March 13, 2016

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Circular RNAs (circRNAs) are abundant in the brain, but their role in experience-dependent plasticity is unknown.
Synaptic development and plasticity are known to alter circRNA expression in vitro.

Purpose of the Study:

To investigate the role of circRNAs in experience-dependent plasticity in the mouse visual cortex in vivo.
To examine the function of circHomer1 in synaptic development and plasticity following monocular deprivation.

Main Methods:

Transcriptome-wide analysis of juvenile mouse visual cortex after 3-day monocular deprivation.
Gene knockdown of circHomer1 to assess its functional impact.
Analysis of dendritic spine size and surface AMPA receptor expression.

Main Results:

Monocular deprivation led to opposing expression changes in circHomer1 (increased) and Homer1a (decreased).
circHomer1 knockdown delayed visual response depression and impaired structural plasticity.
circHomer1 knockdown prevented the reduction of surface AMPA receptors.

Conclusions:

circHomer1 is crucial for normal synaptic development in the visual cortex.
circHomer1 plays an essential role in experience-dependent synaptic plasticity.