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Bone Morphogenetic Proteins in Orthopedics: A Bibliometric Analysis.

Shichao Liu1, Xiongjie Xu1, Jingyu Zhou2

  • 1Fujian Medical University Union Hospital, Fuzhou, 350001 Fujian China.

Indian Journal of Orthopaedics
|October 7, 2025
PubMed
Summary

This bibliometric analysis reveals sustained research in bone morphogenetic proteins (BMPs) for orthopedics. Key areas include spinal fusion, tissue engineering, and stem cell differentiation, with frontiers in BMP delivery systems.

Keywords:
BibliometricsBone morphogenetic proteinsBone tissue engineeringDelivery systemsOrthopedics

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Area of Science:

  • Orthopedics
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Bone morphogenetic proteins (BMPs) show promise for bone regeneration due to their osteoinductive properties.
  • However, the safety and efficacy of BMPs in orthopedic applications remain subjects of ongoing debate.
  • Bibliometric analysis provides a quantitative approach to understanding research landscapes.

Purpose of the Study:

  • To conduct a bibliometric analysis of Bone Morphogenetic Proteins (BMPs) research in orthopedics.
  • To identify current research trends, hotspots, and emerging frontiers in this field.
  • To provide insights for future research directions in BMPs for orthopedic applications.

Main Methods:

  • A comprehensive literature search was performed in the Web of Science Core Collection.
  • Data spanned English-language articles on BMPs and orthopedic themes from 1900 to 2024.
  • Bibliometric parameters were extracted and analyzed using CiteSpace and Microsoft Excel for network visualization.

Main Results:

  • 1048 articles published over 32 years indicate sustained research activity.
  • The United States leads in productivity, with the University of California System as the top institution.
  • Key research hotspots include spinal fusion, bone tissue engineering, and gene therapy, with frontiers in mesenchymal stem cell differentiation and BMP delivery systems.

Conclusions:

  • This study provides a comprehensive overview of the global research landscape for BMPs in orthopedics.
  • It identifies key contributors, influential journals, and significant research themes.
  • The findings offer directional guidance for future research and development in orthopedic BMP applications.