Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

16.0K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
16.0K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.7K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.4K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.4K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.5K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.5K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

2.9K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a Time-Resolved Fluorescence Immunoassay for BAFF and Its Preliminary Clinical Application in Patients with Lupus Nephritis.

Journal of fluorescence·2026
Same author

Effect of electroacupuncture on motor and sensory functions of lower limbs and GABA receptor in spinal cord of rats with neuropathic pain.

The journal of spinal cord medicine·2026
Same author

Risk prediction of <i>Helicobacter pylori</i> strains across Correa's cascade via intelligent analysis of genome-wide SNPs.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Ultra-Stable 2D Magneto-Fluorescent Probe-Mediated Multiplex Immunochromatographic Assay for Precise Bedside Detection of Sepsis.

ACS nano·2026
Same author

SiO<sub>2</sub> shell-protected magnetic fluorescent tag for on-site ultrasensitive immunodetection of foodborne viruses.

Mikrochimica acta·2026
Same author

Accuracy and Agreement of a 45 mg Versus a 75 mg <sup>13</sup>C-Urea Breath Test for the Diagnosis of <i>Helicobacter pylori</i> Infection in Adults: A Randomized Crossover Trial.

Diagnostics (Basel, Switzerland)·2026
Same journal

Learning Moisture-Induced Damage From Vision: Diffusion Models for Real-Time Monitoring of Additive Manufacturing Processes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Intrinsic Dual-Phase Regulated GeSe<sub>2</sub> Nanoparticles Triggered by Ball-Milling Treatment for Photonic Multi-Valued Logic Circuits.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

A Plant Photoregulator-Inspired S-Type Heterojunction System for Diabetic Keratopathy via Tri-Modal Light-Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Ultrasound-Recharged Sub-Nanometer Palladium Catalysts for on-Demand and Self-Terminating Bioorthogonal Prodrug Activation in Cancer Therapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Graphene Aerogels With Spherical Pore Structure for Broad Frequency Regulation and Enhanced Low-Frequency Response.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
See all related articles

Related Experiment Video

Updated: Jan 15, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

13.0K

B-EPIC: A Transformer-Based Language Model for Decoding B Cell Immunodominance Patterns.

Jun-Ze Liang1, Youtao Wang1, Cong Sun1

  • 1Department of Experimental Research, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|October 7, 2025
PubMed
Summary
This summary is machine-generated.

A new AI tool, B-Epic, accurately predicts B-cell epitopes (BCEs) for vaccine development. This advancement aids in creating effective vaccines against infectious diseases and cancers by identifying promising peptide targets.

Keywords:
B cell epitope predictionImmunodiagnostics designpathogens preventiontransformervaccines development

More Related Videos

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

18.5K
Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
09:49

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells

Published on: August 13, 2010

19.5K

Related Experiment Videos

Last Updated: Jan 15, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

13.0K
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

18.5K
Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
09:49

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells

Published on: August 13, 2010

19.5K

Area of Science:

  • Computational biology
  • Immunoinformatics
  • Artificial intelligence in medicine

Background:

  • Vaccine development faces challenges due to inefficient B-cell epitope (BCE) prediction.
  • Accurate BCE identification is critical for effective vaccine design and disease prevention.

Purpose of the Study:

  • To introduce B-Epic, a novel Transformer-based pipeline for accurate BCE prediction.
  • To validate B-Epic's performance against existing tools and demonstrate its utility in disease prevention.

Main Methods:

  • Development of B-Epic, a pipeline utilizing Transformer architecture for BCE prediction.
  • Validation using diverse datasets, including clinically-approved vaccine targets and large-scale peptide libraries.
  • Application of B-Epic to identify potential vaccine targets for Helicobacter pylori and immunodiagnostic markers for Epstein-Barr virus.

Main Results:

  • B-Epic achieved high AUCs of 0.882 and 0.945 in predicting BCEs and immunoreactive peptides, outperforming other tools.
  • Screened peptides from Helicobacter pylori activated B cells, indicating potential as vaccine candidates.
  • Identified pan-immunoreactive peptides in Epstein-Barr virus, showing higher reactivity in cancer patients, suggesting diagnostic potential.

Conclusions:

  • B-Epic offers a robust and accurate method for BCE prediction, significantly improving upon existing tools.
  • The pipeline facilitates the discovery of novel vaccine targets for infectious agents and carcinogenic pathogens.
  • B-Epic shows promise in advancing both vaccine development and immunodiagnostics for diseases like cancer.