Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

43.2K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.2K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

36.8K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.8K
Karyotyping01:17

Karyotyping

68.1K
Overview
68.1K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.3K
Lethal Alleles02:41

Lethal Alleles

17.7K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
17.7K
Nondisjunction01:29

Nondisjunction

81.8K
During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
81.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Audit to evaluate the clinical presentation and surgical management of acute appendicitis at a secondary-level hospital in the Western Cape.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2026
Same author

Gallbladder tuberculosis: an unlikely diagnosis after laparoscopic cholecystectomy.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2026
Same author

Massive jejunal gastrointestinal stromal tumour bleed - a case report.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2025
See all related articles

Related Experiment Video

Updated: Jan 15, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

9.0K

Wilkie's syndrome: a fortuitous finding.

I N Palkowski1, K Polden1

  • 1General Surgery, George Regional Hospital, South Africa.

South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
|October 7, 2025
PubMed
Summary

Superior mesenteric artery (SMA) syndrome, or Wilkie's syndrome, is a rare duodenal compression condition. Affecting approximately 500 cases globally, its low incidence highlights its rarity in medical literature.

Keywords:
Wilkie's syndromesuperior mesenteric artery syndrome

More Related Videos

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome
05:12

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome

Published on: September 19, 2019

6.9K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.3K

Related Experiment Videos

Last Updated: Jan 15, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

9.0K
Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome
05:12

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome

Published on: September 19, 2019

6.9K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.3K

Area of Science:

  • Gastroenterology
  • Vascular Surgery
  • Rare Diseases

Background:

  • Superior mesenteric artery (SMA) syndrome, also known as Wilkie's syndrome, involves duodenal compression.
  • This occurs between the abdominal aorta and the superior mesenteric artery.
  • It is a rare condition with limited documented cases.

Purpose of the Study:

  • To summarize the current understanding of SMA syndrome.
  • To highlight its rarity and incidence based on available literature.

Main Methods:

  • Literature review of documented cases of SMA syndrome.
  • Analysis of reported incidence rates from global studies.

Main Results:

  • Approximately 500 cases of SMA syndrome have been reported worldwide.
  • The reported incidence ranges from 0.013% to 0.3%.

Conclusions:

  • SMA syndrome is a rare condition with a low reported incidence.
  • The limited number of cases underscores the need for continued awareness and research.