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Enzyme-Based Electrochemical Sensing Systems for On-Site Detection: Recent Progress and Prospects
Huiwen Wang1, Cong Liu1, Tingting Feng2
1Guangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, China.
Small (Weinheim an Der Bergstrasse, Germany)
|October 7, 2025
Summary
Enzyme-based electrochemical sensors are advancing for rapid health monitoring. Innovations in electrode technology improve stability and sensitivity for point-of-care testing (POCT), though challenges remain for widespread use.
Area of Science:
- Electrochemistry
- Biosensors
- Biomedical Engineering
Background:
- Growing demand for rapid and reliable health monitoring fuels advancements in enzyme-based electrochemical sensors.
- Point-of-care testing (POCT) requires sensitive and accurate diagnostic tools for critical health biomarkers.
Purpose of the Study:
- To review recent developments in enzyme electrode technology for electrochemical sensors.
- To highlight innovations enhancing sensor stability, sensitivity, and accuracy.
- To discuss challenges and future directions for enzyme-based electrochemical sensors in healthcare.
Main Methods:
- Review of recent literature on enzyme electrode technology.
- Focus on surface modifications, immobilization techniques, and electrode materials.
- Analysis of sensor integration with portable and smart technologies.
Main Results:
- Surface modifications, immobilization techniques, and electrode materials significantly enhance sensor performance.
- Integration with portable devices and smart technologies increases practicality for clinical diagnostics.
- Advances position these sensors as valuable tools for health monitoring.
Conclusions:
- Enzyme-based electrochemical sensors show great promise for POCT and health monitoring.
- Continued research is needed to overcome challenges for diverse environmental applications.
- These sensors are crucial for the future of accessible and efficient healthcare diagnostics.
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