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Updated: Jan 15, 2026

Assisted Selection of Biomarkers by Linear Discriminant Analysis Effect Size LEfSe in Microbiome Data
Published on: May 16, 2022
Digest: Theoretical advances in studying selection via microbiome-mediated traits
1Biology Department, University of Puerto Rico at Mayagüez, Mayagüez, Puerto Rico.
Abstract:
How do microbes associated with multicellular hosts contribute to host evolution, and how do factors such as mode of transmission mediate these contributions? Week et al. (2025) provide a theoretical framework to address these questions and through simulation show that microbial transmission mode can have varying effects that interact with host life history. This expands our potential to understand host-microbiome dynamics and illustrates that a quantitative genetic framework provides a more accurate view of organismal evolution than correlative analyses of siloed datasets.
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