Related Experiment Video
Updated: Jan 15, 2026

Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits
Published on: February 28, 2025
Multimorbidity and the Risk of Sudden Cardiac Death: Findings From a Prospective Cohort Study
Jari A Laukkanen1, Jussi Kauhanen2, Sudhir Kurl3
1Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Wellbeing Services County of Central Finland, Department of Medicine, Jyväskylä, Finland.
Objective:
To assess the prospective associations of multimorbidity status and level with the risk of sudden cardiac death (SCD).
Methods:
Multimorbidity was defined as the presence of at least two multiple long-term conditions (hypertension, cardiovascular disease, type 2 diabetes, chronic kidney disease, chronic bronchitis, and other chronic lung conditions) among 2598 men 42 to 61 years of age who were recruited into the KIHD (Kuopio Ischemic Heart Disease) study from March 1, 1984, to December 31, 1989. Hazard ratios with 95% CIs were estimated.
Results:
During a median follow-up of 27.8 years, 296 SCDs were recorded. In analysis adjusted for several established cardiovascular risk factors including socioeconomic and lifestyle characteristics, the HR (95% CI) for SCD comparing men with multimorbidity vs no multimorbidity was 1.97 (95% CI, 1.54 to 2.51). Compared with men with no multimorbidity, the corresponding adjusted HRs (95% CIs) for SCD were 1.93 (95% CI, 1.50 to 2.47) for men with two to three conditions and 2.66 (95% CI, 1.34 to 5.28) for men with four to five conditions.
Conclusion:
In middle-aged and older men, multimorbidity is strongly linked to an increased risk of SCD, independent of known cardiovascular risk factors. Furthermore, the risk of SCD rises progressively with the number of coexisting health conditions.
More Related Videos
06:55Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
08:51Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
Related Concept Videos
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Coronary Artery Disease III: Clinical Manifestations
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Acute Coronary Syndrome III: Diagnostic Studies
Cardiomyopathy I: Introduction and Classification
Coronary Artery Disease IV: Preventive Measures