Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Monitoring the Response of Treatment in Major Depressive Disorder with EEG: Could it be an Indicator of Returning to Health in Responders.

Clinical EEG and neuroscience·2025

Same author

Multimodal Neuroimaging in the Prediction of Deep TMS Response in OCD.

Clinical EEG and neuroscience·2024

Same author

A Way to Increase the Sensitivity and Specificity of the Hamilton Depression and Anxiety Scales.

Psychiatry and clinical psychopharmacology·2024

Same author

P300 parameters in major depressive disorder: A systematic review and meta-analysis.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2024

Same author

Statistical Comparison Between Interview Questions and Rating Scales in Psychiatry.

Alpha psychiatry·2023

Same author

Predictive Value of qEEG in Manic Switch of Depressed Patients.

Clinical EEG and neuroscience·2023

Search research articles

Related Experiment Video

Updated: Jan 6, 2026

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

State-Dependent qEEG Biomarkers in Depression.

Mehmet Kemal Arıkan¹, Reyhan Ilhan¹

¹Kemal Arıkan Psychiatry Clinic, Istanbul, Turkey.

Clinical EEG and Neuroscience

|October 7, 2025

Summary

Quantitative electroencephalography (qEEG) reveals distinct brain activity patterns in major depressive disorder (MDD) patients. Responders showed normalizing brain activity, while non-responders had persistent alterations, indicating qEEG

Keywords:

EEG alpha delta major depressive disorder state marker

More Related Videos

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Related Experiment Videos

Last Updated: Jan 6, 2026

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Area of Science:

Neuroscience
Psychiatry
Biomarkers

Background:

Identifying state biomarkers for major depressive disorder (MDD) is crucial for understanding its neurobiological basis.
Quantitative electroencephalography (qEEG) shows promise in differentiating stable versus dynamic neural alterations in MDD.

Purpose of the Study:

To investigate longitudinal changes in qEEG activity in MDD patients undergoing treatment.
To identify qEEG state-markers associated with treatment response and clinical improvement in MDD.

Main Methods:

Recruited 70 MDD patients and 98 healthy controls (HC).
Acquired resting-state qEEG at baseline (T0), early treatment (T1), and late treatment (T2).
Categorized patients into responders (≥50% HDRS-21 reduction) and non-responders; analyzed absolute band power and correlated qEEG with HDRS/HARS scores.

Main Results:

MDD responders exhibited longitudinal reductions in delta power, moving towards HC levels, with marginal increases in gamma activity.
Non-responders displayed persistently elevated delta and alpha power across all sessions.
Reduced fronto-central delta and increased left fronto-central gamma power correlated with improved depression and anxiety.

Conclusions:

MDD responders demonstrated state-dependent electrophysiological normalization during treatment.
Non-responders showed stable, unchanged qEEG patterns consistent with their persistent depressive state.
qEEG state-markers are valuable for monitoring clinical progress in depression.