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Updated: Jan 15, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
SMARCA4 -deficient Non-small Cell Lung Carcinoma Harboring ALK Fusion : A Case Report
Anne-Laure Désage1, Simon Pointel1, Eric Ezingeard2
1Department of Pulmonology and Thoracic oncology, University Hospital of Saint-Etienne.
Abstract:
SMARCA4 -deficient non-small cell lung cancers are usually of poor prognosis and associated with smoking-related mutations. Here, we report the case of a SMARCA4 -deficient non-small cell lung cancer (NSCLC) occurring in a non-smoker female and harboring ALK fusion. Our case highlights for physicians to be especially cautious with molecular biological results in case of SMARCA4 -deficient non-small cell lung cancer occurring in nonsmokers.

