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Optical scattering coefficient measurement of blood plasma during clot formation
Lea Abi Nassif1, Wadih Khater1, Fabrice Pellen1
1Laboratory of Optics and Magnetism OPTIMAG UR 938, IBSAM, Univ Brest, F-29200 Brest, France.
Objective. Venous Thromboembolism (VTE) is a very dangerous and common disease. While approximately 50% of VTE can be attributed to identifiable causes, the remaining half has no known origin and about 30% of this group show recurrence. Monitoring the kinetics of optical scattering properties of plasma during clot formation can provide information on clot structure, which seems to be a relevant parameter to identify patients at risk of recurrence.Approach. This study aims to compare a sensitive and quantitative optical method based on the scattering coefficientμsmeasurement, never previously explored in the context of VTE, to the conventional optical density (OD) measurement obtained by a spectrophotometer.Main results. The evolution of eight characteristic parameters, extracted from clot formation curve signatures, was studied as a function of plasma concentration.Significance. Scattering coefficient measurements are sensitive to plasma concentration in the sample, more reproductible, more precise and provide access to new information compared to OD measurements.
Objective. Venous Thromboembolism (VTE) is a very dangerous and common disease. While approximately 50% of VTE can be attributed to identifiable causes, the remaining half has no known origin and about 30% of this group show recurrence. Monitoring the kinetics of optical scattering properties of plasma during clot formation can provide information on clot structure, which seems to be a relevant parameter to identify patients at risk of recurrence.Approach. This study aims to compare a sensitive and quantitative optical method based on the scattering coefficientμsmeasurement, never previously explored in the context of VTE, to the conventional optical density (OD) measurement obtained by a spectrophotometer.Main results. The evolution of eight characteristic parameters, extracted from clot formation curve signatures, was studied as a function of plasma concentration.Significance. Scattering coefficient measurements are sensitive to plasma concentration in the sample, more reproductible, more precise and provide access to new information compared to OD measurements.
