Agreement and repeatability of ocular surface function using the S390L Firefly WDR slitlamp compared with Keratograph...

Area of Science:

• Ophthalmology
• Biomedical Engineering
• Optometry

Background:

• Dry eye disease diagnosis relies on accurate tear film parameter assessment.
• The Keratograph 5M is a standard device for measuring tear film parameters.
• The S390L Firefly WDR slitlamp is a novel device for ocular surface analysis.

Purpose of the Study:

• To evaluate the agreement and repeatability of the S390L Firefly WDR slitlamp compared to the Keratograph 5M.
• To assess the clinical utility of the S390L Firefly WDR slitlamp for tear film measurements.

Main Methods:

• Prospective study involving 44 subjects.
• Tear film parameters measured: first non-invasive tear break-up time (NIBUTf), average non-invasive tear break-up time (NIBUTav), and tear meniscus height (TMH).
• Statistical analysis included Bland-Altman plots for agreement and Intraclass Correlation Coefficient (ICC) for repeatability.

Main Results:

• No significant differences were found in paired comparisons of NIBUTf, NIBUTav, and TMH between the two devices.
• Bland-Altman analysis indicated good agreement for NIBUTf, NIBUTav, and TMH.
• High ICC values (0.89 for NIBUTf, 0.84 for NIBUTav, 0.98 for TMH) demonstrated excellent repeatability for the S390L Firefly WDR slitlamp.

Conclusions:

• The S390L Firefly WDR slitlamp demonstrates good repeatability and acceptable agreement with the Keratograph 5M for tear film parameter measurement.
• The S390L Firefly WDR slitlamp can be considered a reliable alternative to the Keratograph 5M in clinical settings.
• The device offers acceptable intrasession repeatability for the clinical evaluation of tear film parameters.