A One Health framework for global and local stewardship across the antimicrobial lifecycle

Area of Science:

• One Health
• Antimicrobial Resistance
• Global Health Security

Background:

• Antimicrobial resistance (AMR) poses a significant One Health challenge, impacting human and animal health, agriculture, and ecosystems.
• AMR has profound consequences for public health, food security, and global economies.
• Addressing AMR necessitates integrated stewardship across all sectors and lifecycle stages.

Purpose of the Study:

• To propose a comprehensive One Health stewardship framework for antimicrobials.
• To cover the entire antimicrobial lifecycle from innovation to disposal.
• To integrate stewardship across human, animal, plant, and environmental sectors.

Main Methods:

• The study outlines a framework based on World Health Organization (WHO), Food and Agriculture Organization (FAO), and World Organization for Animal Health (WOAH) guidelines.
• It emphasizes stewardship principles across six key stages: R&D, production, authorization, procurement, use, and disposal.
• The framework integrates innovation, access, use, and disposal stewardship.

Main Results:

• The proposed framework provides end-to-end stewardship for antimicrobials.
• It aims to maintain the efficacy of existing and new antimicrobial agents.
• The framework supports optimal infection management and prevention across One Health sectors.

Conclusions:

• Implementing this comprehensive One Health stewardship framework is crucial for preserving antimicrobial efficacy.
• This approach helps mitigate the spread of antimicrobial resistance.
• The framework safeguards global health, animal health, food security, and ecosystem integrity.