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Related Concept Videos

Metabolic States of the Body: Fasting and Starvation01:24

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During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
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The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
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Related Experiment Video

Updated: Jan 15, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Prolonged fasting for optimizing myocardial fluorodeoxyglucose suppression.

Fatima Abdullahi1, Khalid Makhdomi1, Jasmit Shah2,3

  • 1Department of Radiology.

Nuclear Medicine Communications
|October 8, 2025
PubMed
Summary
This summary is machine-generated.

Fasting for 18 hours or more effectively suppresses physiological myocardial uptake of 18F-FDG, aiding in the diagnosis of cardiac inflammation. This simple protocol is reproducible and valuable, especially in resource-limited settings.

Keywords:
PET/CTfasting durationmyocardial fluorodeoxyglucose uptakephysiological uptake suppression

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Area of Science:

  • Nuclear medicine
  • Cardiology
  • Medical imaging

Background:

  • 18F-fluorodeoxyglucose (18F-FDG) PET is crucial for diagnosing cardiac inflammatory disorders.
  • Physiological myocardial uptake of 18F-FDG can interfere with detecting pathological uptake.
  • Suppression of physiological uptake is necessary for accurate cardiac inflammation assessment.

Purpose of the Study:

  • To evaluate the efficacy of fasting duration in suppressing physiological myocardial 18F-FDG uptake.
  • To establish a practical imaging protocol for cardiac inflammation evaluation.
  • To determine the optimal fasting period for PET imaging.

Main Methods:

  • Retrospective review of 450 patients undergoing whole-body 18F-FDG PET/CT for oncologic indications.
  • Patients categorized into three fasting groups: <12h, 12-17h, and ≥18h.
  • Qualitative grading of myocardial FDG uptake by two independent readers; interreader agreement assessed using Cohen's Kappa.

Main Results:

  • Adequate myocardial suppression rates were 60% (<12h), 66% (12-17h), and 77.3% (≥18h) (P=0.005).
  • Fasting duration ≥18h showed significantly higher suppression rates.
  • Suppression was associated with gender and BMI, but not blood glucose, age, or diabetes. Interreader agreement was excellent (Cohen's Kappa 0.909).

Conclusions:

  • Fasting for ≥18 hours is superior for suppressing physiological myocardial 18F-FDG uptake.
  • This extended fasting protocol enhances the evaluation of myocardial inflammation.
  • The simple, reproducible visual grading method is suitable for clinical practice, particularly in resource-limited settings.