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Updated: Jan 15, 2026
An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
Published on: January 26, 2019
Respiratory syncytial virus. What's new in prevention?
Nestor E Vain1, Paolo Manzoni2, Kee Thai Yeo3
1Hospital Sanatorio Trinidad, Buenos Aires, Argentina; School of Medicine, University of Buenos Aires, Argentina.
Insights
New vaccines and monoclonal antibodies offer effective prevention against Respiratory Syncytial Virus (RSV) lower respiratory tract infections (LRTI) in infants. These advancements provide broad protection, significantly improving infant public health outcomes.
Area of Science:
- Pediatrics
- Immunology
- Public Health
Background:
- Infant Respiratory Syncytial Virus (RSV) lower respiratory tract infections (LRTI) prevention was limited.
- Palivizumab, a monoclonal antibody, was restricted to high-risk infants.
- Maternal RSV vaccination and new monoclonal antibodies offer expanded protection.
Purpose of the Study:
- To review the effectiveness of new RSV prevention strategies in infants.
- To highlight the impact of maternal vaccination and extended half-life monoclonal antibodies.
- To discuss the role of these strategies in infant immunization programs.
Main Methods:
- Review of randomized controlled trials (RCTs) and real-life monitoring data.
- Analysis of nirsevimab and clesrovimab effectiveness.
- Evaluation of maternal vaccine-induced antibody transfer and infant protection.
Main Results:
- Maternal RSV vaccines demonstrate effectiveness in protecting newborns.
- Novel monoclonal antibodies like nirsevimab show significant reduction in RSV-LRTI incidence.
- Large-scale prophylaxis with nirsevimab has a substantial public health impact.
Conclusions:
- New immunologic agents, including maternal vaccines and monoclonal antibodies, offer robust RSV prevention for infants.
- These strategies, alone or combined, can complement existing immunization programs.
- Expanded use of these interventions promises to significantly decrease RSV-LRTI burden in infants.
Abstract:
Prevention of RSV lower respiratory tract infections (LRTI) in infants has been limited to general measures and palivizumab, a monoclonal antibody indicated for the highest risk groups. Recently developed RSV vaccines used during pregnancy generate antibodies that cross the placenta. Randomized controlled trials (RCT) and real-life monitoring have demonstrated their effectiveness in protecting newborns and infants during the first months of life. Likewise, novel extended half-life monoclonal antibodies, nirsevimab and the recently approved clesrovimab, opened the possibility of large-scale protection targeted to all infants born during the winter season and those <6 months at the beginning of it. Several RCTs and results from populations adopting nirsevimab prophylaxis demonstrated a large decrease in the incidence of RSV-LRTIs and a great impact in infant public health. Deployment of either strategies or in combination as part of immunization programs can be complement each other even as newer immunologic agents are being introduced.
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