Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Introduction to Mechanisms of Enzyme Catalysis

Introduction to Mechanisms of Enzyme Catalysis

For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low-Energy Photocatalytic C-H Amination of Arenes Enabled by an Orange-Light Organic Photooxidant.

Organic letters·2026

Same author

Steroids in organ transplantation: Immunosuppression and tolerance.

The Journal of steroid biochemistry and molecular biology·2026

Same author

Theileria annulata antibody level to clinical surveillance of disease progression and parasite stage differentiation in bovine host.

Microbial pathogenesis·2026

Same author

QuantumNeuroXAI: a quantum-inspired deep learning framework with explainability for brain signal analysis and neurological disorder detection.

Scientific reports·2026

Same author

Sustainable strategies for remediation of Cr(VI) contaminated soil and water bodies: exploring the potential of invasive bamboo and its derivatives.

Frontiers in plant science·2026

Same author

Therapeutic potential of goat whey protein hydrolysate and vitamin-D<sub>3</sub> in combating D-galactose-induced sperm senescence in male mice.

F&S science·2026

Same journal

Nickel-Photochemical C-N Couplings: Moving Beyond Iridium Photocatalysts.

Trends in chemistry·2026

Same journal

Nickel-Mediated Aerobic C<i>sp</i> <sup><i>2</i></sup> -Nucleophile Coupling.

Trends in chemistry·2026

Same journal

The Curious Case of β-Boryl Triplet States.

Trends in chemistry·2026

Same journal

Asymmetric Partial Reductions of Pyridines.

Trends in chemistry·2025

Same journal

Transforming bio-derived DNA into biotechnology.

Trends in chemistry·2025

Same journal

Expanding Epitranscriptomics to Non-Enzymatic RNA Modifications.

Trends in chemistry·2025

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 15, 2026

Detection and Recovery of Palladium, Gold and Cobalt Metals from the Urban Mine Using Novel Sensors/Adsorbents Designated with Nanoscale Wagon-wheel-shaped Pores

Detection and Recovery of Palladium, Gold and Cobalt Metals from the Urban Mine Using Novel Sensors/Adsorbents Designated with Nanoscale Wagon-wheel-shaped Pores

Published on: December 6, 2015

Transition Metal Catalysis Drives Innovative Activity-Based Sensing Systems.

Autumn I Giger^1,2, Ramandeep Kaur^1,2, Nicholas J Dacon^1,2

¹Department of Chemistry and Biochemistry, University of Denver, Denver, CO, 80210, United States.

Trends in Chemistry

|October 8, 2025

Summary

This summary is machine-generated.

Mechanistic understanding drives advances in transition metal catalysis, enabling new applications in molecular sensing through improved ligand design. This research explores how insights into reaction mechanisms have shaped this field.

More Related Videos

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks

Published on: May 26, 2023

Author Spotlight: Magnetometric Characterization of Intermediates in the Solid-State Electrochemistry of Redox-Active Metal-Organic Frameworks

Author Spotlight: Magnetometric Characterization of Intermediates in the Solid-State Electrochemistry of Redox-Active Metal-Organic Frameworks

Published on: June 9, 2023

Related Experiment Videos

Last Updated: Jan 15, 2026

Detection and Recovery of Palladium, Gold and Cobalt Metals from the Urban Mine Using Novel Sensors/Adsorbents Designated with Nanoscale Wagon-wheel-shaped Pores

Detection and Recovery of Palladium, Gold and Cobalt Metals from the Urban Mine Using Novel Sensors/Adsorbents Designated with Nanoscale Wagon-wheel-shaped Pores

Published on: December 6, 2015

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks

Published on: May 26, 2023

Author Spotlight: Magnetometric Characterization of Intermediates in the Solid-State Electrochemistry of Redox-Active Metal-Organic Frameworks

Author Spotlight: Magnetometric Characterization of Intermediates in the Solid-State Electrochemistry of Redox-Active Metal-Organic Frameworks

Published on: June 9, 2023

Area of Science:

Organic Chemistry
Catalysis
Molecular Sensing

Background:

Transition metal catalysis is a vital tool in organic synthesis.
Ligand design innovations are expanding catalytic applications.
Mechanistic understanding is crucial for advancing chemical technologies.

Purpose of the Study:

To contextualize the influence of mechanistic insight on transition metal-based molecular sensing.
To highlight recent developments driven by mechanistic understanding in this area.

Main Methods:

Review of recent literature on transition metal catalysis and molecular sensing.
Analysis of case studies demonstrating the impact of mechanistic studies.
Synthesis of current trends and future directions.

Main Results:

Mechanistic insights have directly led to the development of novel transition metal catalysts for sensing applications.
Improved ligand design, informed by mechanistic studies, enhances selectivity and sensitivity in molecular sensors.
The integration of mechanistic understanding accelerates innovation in the field.

Conclusions:

Mechanistic understanding is a key driver for progress in transition metal-based molecular sensing.
Continued focus on mechanistic studies will unlock further advancements in ligand design and sensor technology.
This field holds significant potential for future applications in chemical detection and analysis.