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Recombinant human mitsugumin 53: a potential therapeutic agent for multiple diseases.

Junfeng Li1, Jingjing Shen2, Tian Li3,4,5,6

  • 1Department of Oncology of Zaozhuang Hospital of Zaozhuang Mining Group, Zaozhuang, Shandong, China.

Frontiers in Pharmacology
|October 8, 2025
PubMed
Summary

Mitsugumin 53 (MG53) protein aids muscle repair and protects organs from injury. Recombinant human MG53 (rhMG53) shows therapeutic potential across various diseases, including cardiovascular and multiple-organ injuries.

Keywords:
acute lung injurycardiovascular diseaseskidney injuryrecombinant human MG53tumor

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Mitsugumin 53 (MG53) is a muscle-expressed protein vital for sarcolemmal membrane repair.
  • MG53 also functions in non-striated tissues like lung, kidney, and immune cells.
  • Endogenous MG53 plays a protective role in cardiac ischemia/reperfusion injury.

Purpose of the Study:

  • To review the therapeutic functions of recombinant human MG53 (rhMG53).
  • To elucidate the molecular mechanisms underlying rhMG53's protective effects in multiple organ injuries.
  • To highlight rhMG53's potential as a therapeutic agent for diverse diseases.

Main Methods:

  • Literature review of studies on MG53 and rhMG53.
  • Analysis of molecular mechanisms in various disease models.
  • Synthesis of evidence for rhMG53's broad therapeutic applications.

Main Results:

  • rhMG53 demonstrates protective effects in skeletal muscle injury models.
  • rhMG53 shows efficacy in cardiovascular disease and multiple-organ injury contexts.
  • Studies confirm rhMG53's broad protective capabilities.

Conclusions:

  • rhMG53 exhibits significant therapeutic potential for multiple organ injuries.
  • Understanding rhMG53's mechanisms supports its development as a novel therapeutic agent.
  • rhMG53 represents a promising candidate for treating a wide range of diseases.