Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

677
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
677
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

150
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
150
Measurement of Bioavailability: Pharmacodynamic Methods01:20

Measurement of Bioavailability: Pharmacodynamic Methods

233
Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.
233
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

192
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
192
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

166
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
166
Genetic Screens02:46

Genetic Screens

5.6K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing imatinib sampling strategies through a population approach: a crucial step to model-informed precision dosing validation for point-of-care therapeutic drug monitoring.

BMC pharmacology & toxicology·2026
Same author

Evaluating Bayesian Vancomycin Dosage Adjustment in Neonates: A Simulation-Based Virtual TDM Study.

Clinical pharmacokinetics·2026
Same author

Pelargonium sidoides extract (EPs® 7630) versus usual care for acute bronchitis in Swiss primary care (PHYTOBRONCH): a pragmatic, open-label, randomised controlled trial.

NPJ primary care respiratory medicine·2026
Same author

Population pharmacokinetics of encorafenib and binimetinib in real-world patients with BRAF<sup>V600E/K</sup>-mutant metastatic melanoma.

Cancer chemotherapy and pharmacology·2026
Same author

Model-Based Strategy for 6-Mercaptopurine Treatment in Acute Lymphoblastic Leukemia Maintenance Phase: Prediction of 6-TGN and 6-MMP Concentrations to Optimize Treatment.

Pediatric blood & cancer·2026
Same author

Challenges in performing clinical research on herbal products - experiences from Switzerland and the UK.

Frontiers in pharmacology·2026

Related Experiment Video

Updated: Jan 15, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.6K

Implementing pharmacogenetic testing in community pharmacy practice: a scoping review.

Aude Coumau1,2,3,4, Claire Coumau1,2,3,4, Chantal Csajka1,2,3,4

  • 1Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Frontiers in Pharmacology
|October 8, 2025
PubMed
Summary

Pharmacogenetics (PGx) testing in community pharmacies shows promise for improving medication outcomes. While feasible and accepted by patients and pharmacists, challenges remain in prescriber adoption and guideline standardization for routine clinical integration.

Keywords:
community pharmacy servicesimplementation sciencepharmacogeneticsprecision medicinescoping review

More Related Videos

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

10.2K
Infinium Assay for Large-scale SNP Genotyping Applications
13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

39.8K

Related Experiment Videos

Last Updated: Jan 15, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.6K
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

10.2K
Infinium Assay for Large-scale SNP Genotyping Applications
13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

39.8K

Area of Science:

  • Pharmacogenetics and implementation science.
  • Healthcare delivery and pharmacy practice research.

Background:

  • Pharmacogenetics (PGx) enhances medication effectiveness and reduces adverse drug events.
  • Limited integration of PGx into routine clinical practice despite its benefits.
  • Community pharmacies are accessible points for healthcare interventions.

Purpose of the Study:

  • To conduct a scoping review on the implementation of PGx testing in community pharmacies.
  • To identify successful strategies and challenges in embedding PGx services.
  • To provide an overview of implementation outcomes such as feasibility, acceptability, and sustainability.

Main Methods:

  • Systematic literature search of PubMed, Embase, Cochrane Library, and Web of Science up to February 2025.
  • Inclusion of 17 studies reporting on PGx testing implementation in community pharmacies.
  • Classification of findings using Proctor's implementation outcomes framework.

Main Results:

  • PGx testing implementation was feasible with manageable time and high technical success.
  • Appropriateness was demonstrated by identifying medication-related issues.
  • Patient adoption and acceptance were high, but prescriber integration of recommendations was inconsistent.

Conclusions:

  • PGx testing has potential for routine care in community pharmacies, supported by positive patient and pharmacist perceptions.
  • Barriers include lack of standardized guidelines, provider education needs, and reimbursement issues.
  • Successful implementation requires patient education, workflow integration, and ongoing research.