Primary Localized Conjunctival Amyloidosis Mimicking Lymphoma

A 27-year-old healthy male presented to our clinic with complaints of redness and burning in his left eye for the past 6 months. Biomicroscopic examination revealed a salmon-colored, elevated, painless mass lesion involving the entire lower fornix conjunctiva of the left eye. A conjunctival incisional biopsy was performed due to suspicion of lymphoproliferative disease. Histopathological examination confirmed amyloidosis. Further investigations did not reveal any evidence of systemic amyloidosis, lymphoma, or other lymphoproliferative diseases. During the 18-month follow-up after surgery, no recurrence or new findings were observed in the patient's ophthalmologic or systemic evaluations. Amyloidosis in the periocular region can present with various clinical findings. Although a classic salmon-colored conjunctival mass initially may suggest lymphoproliferative diseases, conjunctival amyloidosis should be considered in the differential diagnosis.