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Immunotherapy in conversion therapy for gastric cancer: current status, progress, and challenges
Yi Su1, Xin Zhang1, Wei Deng1,2
1Department of Digestive Oncology, Beijing Chaoyang Integrative Medicine Rescue and First Aid Hospital, Beijing, China.
Frontiers in Oncology
|October 8, 2025
Summary
Conversion therapy using immunotherapy offers new hope for unresectable gastric cancer. Combining immunotherapy with other treatments shows promise for improving patient survival and enabling surgical resection.
Area of Science:
- Oncology
- Gastroenterology
- Immunotherapy
Background:
- Gastric cancer presents a significant global health challenge, often diagnosed late, leading to poor prognoses.
- Conversion therapy aims to render unresectable gastric tumors operable through systemic treatments, potentially improving long-term survival.
- Immunotherapy has emerged as a promising approach in managing advanced gastric cancer.
Purpose of the Study:
- To review current evidence on immunotherapy-based conversion strategies for gastric cancer.
- To highlight the role of key biomarkers in predicting treatment response.
- To explore future directions in precise, multi-modal treatment approaches.
Main Methods:
- Systematic review of current literature on conversion therapy for gastric cancer.
- Analysis of studies combining immunotherapy with chemotherapy, anti-angiogenic drugs, or chemoradiotherapy.
- Evaluation of biomarker data associated with treatment efficacy.
Main Results:
- Combination therapies involving immunotherapy have demonstrated significant efficacy in select gastric cancer patients.
- Biomarkers play a crucial role in identifying patients who may benefit from these conversion strategies.
- Immunotherapy-based conversion therapy can potentially facilitate tumor resection in previously unresectable cases.
Conclusions:
- Immunotherapy-based conversion strategies represent a significant advancement in the management of unresectable gastric cancer.
- Personalized treatment approaches, guided by biomarkers, are essential for optimizing outcomes.
- Future research should focus on refining multi-modal treatment protocols for enhanced efficacy and patient survival.
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