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Updated: Jan 6, 2026

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Post-translational modifications in heat stress-related diseases
1Clinical Laboratory, Bethune International Peace Hospital, Shijiazhuang, Hebei, China.
None:
Post-translational modifications (PTMs) act as pivotal molecular hubs integrating heat stress signals into cellular responses driving heat-related diseases like heatstroke. This review synthesizes evidence demonstrating that dynamic PTM networks-including phosphorylation, acetylation, ubiquitination, methylation, SUMOylation, and S-nitrosylation-orchestrate pathophysiology through three distinctive mechanisms: PTM crosstalk, tissue-specific PTM signatures defining organ vulnerability, and translational utility. The potentials of PTM alterations as novel biomarkers for early diagnosis/prognosis and PTM-targeted interventions as therapeutic strategies are discussed. By delineating how PTMs reconfigure proteostasis, metabolism, and inflammation, this review provides a mechanistic framework for targeting PTM pathways to mitigate heatstroke and related conditions.
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