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Related Concept Videos

Alterations in Blood Pressure01:30

Alterations in Blood Pressure

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Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
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Factors affecting Blood pressure01:28

Factors affecting Blood pressure

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Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
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Special considerations while measuring blood pressure01:28

Special considerations while measuring blood pressure

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When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Pre-Procedural Guidelines for Assessing Blood Pressure01:10

Pre-Procedural Guidelines for Assessing Blood Pressure

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Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
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Assessing Blood pressure in the Leg01:11

Assessing Blood pressure in the Leg

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Proper measurement of leg blood pressure is a critical skill for healthcare providers, ensuring precise and reliable readings. When performed correctly, this procedure informs patient care and enhances the efficacy of interventions. The following text outlines step-by-step guidelines to measure blood pressure in the leg, providing clarity and ease of understanding for practitioners.
Preparation:
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Updated: Jan 6, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
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Blood Pressure Postural Changes Variability Is Associated With Lower Cognition: The S.AGES Cohort.

Mathilde Strumia1,2, Jean-Sébastien Vidal3,4, Philippe Cestac1,2

  • 1Maintain Aging Research team, CERPOP Université de Toulouse, Inserm, Université Paul Sabatier Toulouse France.

Journal of the American Heart Association
|October 8, 2025
PubMed
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Higher blood pressure (BP) postural changes variability is linked to reduced cognitive function in older adults. This finding suggests that managing BP instability may be important for brain health.

Keywords:
blood pressure postural changes variabilitycognitionolder people

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Area of Science:

  • Gerontology
  • Cardiovascular Health
  • Neuroscience

Background:

  • Blood pressure (BP) variability and postural changes are linked to cognitive decline.
  • Previous research indicates a higher dementia risk with systolic BP (SBP) postural changes variability.
  • The association between BP postural changes variability and cognitive function in community-dwelling older adults requires further investigation.

Purpose of the Study:

  • To investigate the association between BP postural changes variability and cognitive function in community-dwelling older adults.
  • To analyze the relationship between visit-to-visit BP postural changes variability and cognitive performance.

Main Methods:

  • Utilized data from the S.AGES cohort, including 2974 participants (mean age, 78 years) over 3 years.
  • Calculated orthostatic SBP and diastolic BP ratios at 6-month intervals to assess visit-to-visit BP postural changes variability.
  • Employed linear mixed models to analyze the association between BP variability indicators and cognitive function evaluated annually via the Mini-Mental State Examination.

Main Results:

  • Visit-to-visit SBP postural changes variability was significantly associated with lower cognitive function (adjusted β=-0.15, P=0.01).
  • A similar association was observed for visit-to-visit diastolic BP postural changes variability.
  • These findings remained significant after adjusting for demographics, cardiovascular risk factors, seated BP, and BP-lowering treatments.

Conclusions:

  • Visit-to-visit variability in both SBP and diastolic BP postural changes is associated with reduced cognitive function.
  • Further research is warranted to determine if managing orthostatic BP instability can help preserve cognitive function in older adults.