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Published on: November 9, 2019
Organophotoredox and Cobalt-catalyzed 1,2-Difunctionalization of Mono-Donor Cyclopropanes
Jinrong Du1, Jiale Li1, Lebin Qian1
1Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an, 710127, China.
Abstract:
Selective functionalization of unactivated C─C and C─H bonds in mono-donor cyclopropanes represents a significant yet challenging goal in organic synthesis. Although numerous reported studies have documented the 1,3-difunctionalization of these substrates, effective strategies for 1,2-difunctionalization have so far proven elusive. Herein, we report a novel catalytic strategy enabling the 1,2-difunctionalization of mono-donor cyclopropanes. By merging of organophotoredox and cobalt catalytic system, this method achieves selective ring-opening and homobenzylic oxygenation, facilitated by a two-fold sequence involving single electron transfer, nucleophilic addition, and acceptorless dehydrogenation. This unprecedented process overturns the predominant 1,3-selectivity in mono-donor cyclopropane functionalization, concurrently establishing a streamlined platform for forging β-aryl-α'-oxyketone derivatives in a sustainable manner.
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