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Author Spotlight: Integrating 2D-HPLC-MS and Molecular Networking in Natural Medicine Analysis
Published on: December 8, 2023
Three new phenylpropanoids from Atractylodes japonica Koidz. ex kitam
Zhao Sun1, Jing Wang1, Yan Liu1
1Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, People's Republic of China.
Abstract:
Three new phenylpropanoids (1-3), together with eighteen known phenylpropanoids (4-21), were isolated from a 70% aqueous EtOH extract of the rhizomes of Atractylodes japonica Koidz. ex Kitam. Their structures were elucidated by spectroscopic techniques, including 1D, 2D NMR spectra and HR-ESI-MS. All the isolated compounds were evaluated for cytotoxicity activity by CCK-8 assay. Compounds 1, 11 and 13 exhibited moderate activities with IC50 values in the range of 34.19-48.38 μM against human cancer (BGC-823, HepG-2, HeLa) cell lines.
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