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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Aortic valve calcification alone identifies transcatheter aortic valve replacement benefit in classical low-flow,

Yash Prakash1, Eric J Kim1, Ranbir Singh2

  • 1Samuel Bronfman Department of Medicine, Mount Sinai Hospital, New York, New York.

The Journal of Invasive Cardiology
|October 8, 2025
PubMed

Insights

Severe aortic valve calcification (AVC) predicts fewer heart failure rehospitalizations in classical low-flow, low-gradient aortic stenosis (AS) patients. This finding aids in identifying candidates for transcatheter aortic valve replacement (TAVR) when other tests are inconclusive.

Area of Science:

  • Cardiology
  • Medical Diagnostics
  • Interventional Cardiology

Background:

  • Aortic valve calcification (AVC) is recognized for diagnosing low-flow, low-gradient (LFLG) aortic stenosis (AS).
  • The prognostic significance of AVC across different LFLG AS subtypes requires further clarification.

Purpose of the Study:

  • To evaluate the prognostic value of AVC in patients with LFLG AS undergoing transcatheter aortic valve replacement (TAVR).
  • To determine if AVC can identify patients who benefit from TAVR, particularly when dobutamine stress echocardiography (DSE) is inconclusive.

Main Methods:

  • Retrospective cohort study involving 457 patients undergoing TAVR.
  • Analysis of the association between severe AVC and heart failure rehospitalizations across classical and paradoxical LFLG AS subtypes.
  • Correlation of AVC with true-severe AS determined by DSE.

Main Results:

  • Severe AVC was linked to significantly fewer heart failure rehospitalizations in classical LFLG AS (aHR, 0.41; P = .023).
  • No significant association was found between severe AVC and rehospitalizations in paradoxical LFLG AS (aHR, 0.76; P = .422).
  • AVC demonstrated correlation with true-severe AS when DSE was performed.

Conclusions:

  • Severe AVC can serve as a standalone prognostic marker in classical LFLG AS.
  • AVC may help identify patients likely to benefit from TAVR, reducing reliance on DSE when results are unavailable or inconclusive.

Keywords:
TAVRaortic valve stenosislow-flow low-gradient aortic stenosisstress echocardiographytranscatheter aortic valve replacement

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