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Articles linked to this work by shared authors, journal, and citation graph.

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Response to: "From Proof-of-Concept to Decision-Grade Cerebellar Neurostimulation: A Precision-and-Governance Pipeline for Globally Scalable Balance Interventions".

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Related Experiment Video

Updated: Jan 15, 2026

Modulating Cognition Using Transcranial Direct Current Stimulation of the Cerebellum
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Enhancing Balance Control in Aging Through Cerebellar Theta-Burst Stimulation.

Ashwini Sansare1, Madison Weinrich1, Jessica A Bernard2,3

  • 1Department of Kinesiology and Sports Management, Texas A&M University, College Station, TX, USA.

Cerebellum (London, England)
|October 8, 2025
PubMed
Summary
This summary is machine-generated.

A single session of cerebellar intermittent theta-burst stimulation (iTBS) improved standing balance in healthy older adults. This intervention enhanced balance control for at least 30 minutes without altering cerebellar-motor cortex interactions.

Keywords:
Cerebellar Brain Inhibition (CBI)NeuromodulationPostural SwayStanding BalanceTranscranial Magnetic Stimulation (TMS)

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Area of Science:

  • Neuroscience
  • Gerontology
  • Rehabilitation Science

Background:

  • Aging is associated with cerebellar changes impacting balance.
  • The isolated effects of cerebellar intermittent theta-burst stimulation (iTBS) on balance in healthy older adults are unknown.
  • Cerebellar-motor cortex (M1) interactions in aging and balance require further investigation.

Purpose of the Study:

  • To investigate the effects of a single session of cerebellar iTBS on standing balance in healthy older adults.
  • To examine changes in cerebellar-M1 interactions using cerebellar brain inhibition (CBI) after cerebellar iTBS.
  • To determine if cerebellar iTBS can modulate balance and associated neural pathways in aging.

Main Methods:

  • Forty healthy older adults were randomized to receive active or sham cerebellar iTBS.
  • Postural sway was measured using center of pressure (COP) analysis before and after stimulation.
  • Cerebellar brain inhibition (CBI) was assessed to evaluate cerebellar-motor cortex (M1) interactions.

Main Results:

  • Active cerebellar iTBS significantly reduced postural sway compared to sham, indicating improved standing balance.
  • Balance improvements were sustained for at least 30 minutes post-stimulation.
  • Cerebellar iTBS did not significantly alter cerebellar brain inhibition (CBI) measures.

Conclusions:

  • A single session of cerebellar iTBS can effectively improve standing balance in healthy older adults.
  • The cerebellum shows neuroplastic potential for therapeutic interventions targeting balance in aging.
  • Cerebellar iTBS may influence motor control circuits beyond direct cerebellar-M1 pathways.