Related Experiment Video
Updated: Jan 15, 2026
Particle Templated Emulsification enables Microfluidic-Free Droplet Assays
Published on: March 9, 2021
Formulation and optimization of micro-emulgel loaded with Teucrium polium and chicken bile extracts
Fatima Zohra Badaoui1,2, Abdallah Bakhouche1, Soheib Bechkri1
1Department of Pharmaceutical Engineering, Faculty of Processes Engineering, Salah Boubnider University-Constantine 3, Constantine, Algeria.
Objective:
In order to optimize the extraction of Teucrium polium (TP) and chicken bile (Bi), evaluate their biological activities and formulate a micro-emulgel for hemorrhoidal therapy.
Significance:
Teucrium polium and chicken bile have been historically valued for their traditional medicine for treating hemorrhoids. Therefore, they were used for the development of pharmaceutical formulation.
Methods:
A Box-Behnken Design (BBD) was employed to determine the optimal extraction parameters for Teucrium polium, including ethanol/water ratio, extraction time, and material/solvent ratio as factors. The biological activities of both TP and Bi extracts, including antioxidant, antibacterial and anti-inflammatory properties were assessed. The simplex lattice design was used to optimize the formulation of micro-emulgel of both extracts by studying the effect of the surfactant/co-surfactant ratio as well as the oil and water on the spreadability and viscosity of the micro-emulgel. The micro-emulgel was then characterized.
Results:
The Teucrium polium extract demonstrated strong antioxidant and antimicrobial activities, while chicken bile exhibited remarkable anti-inflammatory effect. The optimal micro-emulgel had a good consistency and stability.
Conclusion:
These findings suggest the potential for these natural extracts to be formulated into topical therapies for hemorrhoidal treatment, supporting their traditional use in medicine.
