Time-varying associations between diabetes and mortality following COVID-19: Evidence from a U.S. Veteran population
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View abstract on PubMed
Summary
This summary is machine-generated.Diabetes increased COVID-19 mortality risk, but this risk significantly decreased over time. By mid-2022, mortality risks for individuals with diabetes following COVID-19 infection largely converged with those without diabetes.
Area Of Science
- Public Health
- Epidemiology
- Infectious Diseases
Background
- Previous research indicates diabetes is a risk factor for severe COVID-19 outcomes.
- Limited data exists on how diabetes-associated COVID-19 risks have evolved throughout the pandemic.
Purpose Of The Study
- To investigate the temporal trends of mortality risks associated with diabetes following COVID-19 infection.
- To compare COVID-19 mortality risks between diabetic and non-diabetic individuals over time.
Main Methods
- Retrospective cohort study of 426,170 U.S. Veterans diagnosed with COVID-19 between March 2020 and August 2023.
- Poisson regression models were used to estimate relative risks of 60-day mortality, adjusting for covariates and using weights.
- Interaction terms for time windows were incorporated to analyze risk attenuation over time.
Main Results
- Diabetes was associated with a higher overall risk of 60-day mortality post-COVID-19 (RR=1.21).
- Mortality risks for individuals with diabetes following COVID-19 showed significant attenuation over time.
- By March-August 2022, mortality risks converged with those observed in the non-diabetic population.
Conclusions
- The elevated mortality risk linked to diabetes after COVID-19 infection appears to have diminished over the course of the pandemic.
- Further research is needed to understand the factors contributing to this risk attenuation, such as vaccination, population immunity, and evolving treatment strategies.
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