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Updated: Jan 15, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Visible-Light-Driven One-Pot Synthesis of Polycyclic-Fused Amino-Thiazoles and Amino-Selenazoles via HFIP-Promoted
Nurabul Mondal1, Sunidhi Raj1, Lokman H Choudhury1
1Department of Chemistry, Indian Institute of Technology Patna, Patna 801106, India.
Abstract:
Herein, we report a multicomponent reaction (MCR) involving arylglyoxal, 4-hydroxycoumarin or 4-hydroxy-1-methyl-2(1H)-quinolone, and thiourea or selenourea in the presence of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) and visible light to synthesize novel pentacyclic-fused aminothiazoles and amino-selenazoles. The reaction proceeds via a one-pot, two-step process: first, an HFIP-mediated three-component cyclization with the formation of two C-C bonds, one C-N bond, and one C-S/Se bond that yields trisubstituted aminothiazoles or amino-selenazoles, followed by a photocyclization step under white LED irradiation, which results in the formation of pentacyclic-fused thiazoles or selenazoles. The overall protocol follows green chemistry principles, offering an atom-economical, energy-efficient, and environmentally benign approach under mild reaction conditions and ambient temperature using visible light as a sustainable energy input.
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