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Updated: Jan 15, 2026
11:47
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
12.1K
FGF23: A player not only in bone diseases
Amélie Cifuentes1, Zacharie Laskar-Marchesseau2, Guillaume Courbon1
1Inserm U1059 Sainbiose, University of St Etienne, Mines St Etienne, St Etienne, France.
Joint Bone Spine
|October 8, 2025
Summary
Fibroblast growth factor 23 (FGF23) is an endocrine regulator from bone. Elevated FGF23 levels signal mineral imbalances and cardiovascular risks, even before symptoms appear.
Area of Science:
- Endocrinology
- Mineral Metabolism
- Cardiovascular Science
Background:
- The skeleton functions as an endocrine organ, secreting hormones like fibroblast growth factor 23 (FGF23).
- FGF23 plays a crucial role in phosphate regulation and mineral homeostasis.
- Elevated FGF23 levels are linked to mineral and skeletal disorders.
Purpose of the Study:
- To review the canonical and novel functions of FGF23.
- To highlight FGF23's regulation by non-mineral stressors.
- To explore the link between FGF23 and cardiovascular health.
Main Methods:
- Literature review of FGF23's endocrine functions.
- Analysis of FGF23's role in mineral balance.
- Examination of FGF23's cardiovascular associations.
Main Results:
- FGF23 excess precedes mineral and skeletal disturbances.
- FGF23 is regulated by inflammation, iron deficiency, and glycolysis.
- FGF23 is associated with iron metabolism, erythropoiesis, and cardiac function.
Conclusions:
- FGF23 measurements are valuable for predicting hypophosphatemia and phosphate resistance.
- FGF23 excess can precede hypophosphatemia.
- FGF23 may predict cardiovascular progression in various conditions.
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