Oncological Outcomes of Locally Recurrent Rectal Cancer Treated With Curative Intent: A Single Center Retrospective...

Area of Science:

• Oncology
• Surgical Oncology
• Gastroenterology

Background:

• Treatment for locally recurrent rectal cancer (LRRC) has shifted towards curative-intent multimodal approaches.
• This study evaluates survival outcomes in LRRC patients receiving curative-intent treatment.

Purpose of the Study:

• To assess overall survival (OS), local re-recurrence-free survival (LRFS), and metastasis-free survival (MFS) in LRRC patients.
• To identify prognostic factors influencing survival outcomes in LRRC.

Main Methods:

• Retrospective analysis of 147 LRRC patients treated with curative intent (2014-2024).
• Kaplan-Meier and Cox regression analyses were used to evaluate survival and prognostic factors.
• Outcomes assessed included OS, LRFS, and MFS.

Main Results:

• Median OS was 54 months (5-year OS: 47%). For the 117 patients with curative intent, median OS was 63 months (5-year OS: 58%).
• Achieving clear resection margins (R0) was a significant prognostic factor for improved OS and LRFS.
• In a selected watch-and-wait group (n=8), 5 patients remained alive and disease-free.

Conclusions:

• Curative-intent treatment for LRRC demonstrates favorable oncological outcomes.
• Watch-and-wait strategies warrant further investigation in highly selected LRRC patient cohorts.